产品名称：紫杉醇
拉 丁 名：Chinese yew
提取部位：树皮
提取方法：酒精&酸碱提取
产品外观：白色或类白色粉末
产品规格：99.5%
CAS 号：33069-62-4
抗癌类药品，紫杉醇属有丝分裂中的微管抑制剂，紫杉醇具有聚合和稳定细胞内微管的作用，致使快速分裂的肿瘤细胞在有丝分裂阶段被牢牢固定，使微管不再分开，可阻断细胞于细胞周期之G2与M期，使癌细胞复制受阻断而死亡 。
Production Name:Paclitaxel or Taxol
Original plant:Chinese yew
Specification:99.5%
Test Method:HPLC
Molecular Formula:C47H51NO14
Molecular Weight:853.91
Appearance: White to off-white powder
Solubility:Insoluble in water, soluble in alcoho
CAS No:33069-62-4
Description:Paclitaxel-treated cells have defects in mitotic spindle assembly, chromosome segregation, and cell division. Unlike other tubulin targeted drugs such as colchicine that inhibit microtubule assembly, however, paclitaxel stabilizes the microtubule polymer and protects it from disassembly. The inability of the chromosomes to achieve a metaphase spindle configuration leads to a mitotic block in which there is prolonged activation of the mitotic checkpoint with the subsequent triggering of apoptosis or slippage back into the G1-phase of the cell cycle without cell division.The ability of paclitaxel to inhibit spindle function is generally attributed to its suppression of microtubule dynamics;but recent studies have demonstrated that suppression of dynamics occurs at concentrations lower than those needed to block mitosis. At the higher antimitotic concentrations, paclitaxel appears to act by suppressing microtubule detachment from centrosomes, a process normally activated during mitosis.The binding site for paclitaxel has been shown to reside on the beta-tubulin subunit.